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The physiologic mechanism of erection of the penis involves release of nitric oxide in the corpus cavernosum during sexual stimulation. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but enhances the effect of Nitric oxide by inhibiting phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation occurs, Sildenafil increases levels of cGMP in the corpus cavernosum resulting in smooth muscle relaxation and inflow of blood to the corpus cavemosum.
Kamagra Oral Jelly comes in different doses like 50 mg and 100 mg and with different flavours Pineapple, Orange, Strawberry, Vanilla, Banana, Black Currant, and Butterscotch). For most patients, the recommended dose is 50 mg, as needed approximately 1 hour before the planned intercourse. It is advised to discuss the individual dosage with one?s doctor or pharmacist. Keep in mind that one should apply only one dose of Kamagra Oral Jelly per day and that the dosage should only be increased when advised by a doctor. In such a case and based upon effectiveness and toleration, the dose can be increased to 100 mg or reduced as indicated.